InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EEF2K

Summary

InnateDB Gene

IDBG-19885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF2K

Gene Name

eukaryotic elongation factor-2 kinase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000103319

Encoded Proteins

IDBP-19887

eukaryotic elongation factor-2 kinase

IDBP-747491

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:22206282-22288732

Strand

Forward strand

Band

p12.2

Transcripts

ENST00000263026	ENSP00000263026
ENST00000561791
ENST00000568269	ENSP00000456243
ENST00000563555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004686	elongation factor-2 kinase activity
GO:0005509	calcium ion binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006414	translational elongation
GO:0006468	protein phosphorylation
GO:0008286	insulin receptor signaling pathway
GO:0031952	regulation of protein autophosphorylation
GO:0046777	protein autophosphorylation