InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EEF2K

Summary

InnateDB Protein

IDBP-19887.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF2K

Protein Name

eukaryotic elongation factor-2 kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263026

InnateDB Gene

IDBG-19885 (EEF2K)

Protein Structure

UniProt Annotation

Function

Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269PubMed:14709557, ECO:0000269PubMed:9144159}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004686	elongation factor-2 kinase activity
GO:0005509	calcium ion binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006414	translational elongation
GO:0006468	protein phosphorylation
GO:0008286	insulin receptor signaling pathway
GO:0031952	regulation of protein autophosphorylation
GO:0046777	protein autophosphorylation