Version 5.4
Homo sapiens Gene: RAB11A
Summary
InnateDB Gene IDBG-17737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB11A
Gene Name RAB11A, member RAS oncogene family
Synonyms YL8
Species Homo sapiens
Ensembl Gene ENSG00000103769
Encoded Proteins
IDBP-17739
RAB11A, member RAS oncogene family
IDBP-747330
IDBP-745990
IDBP-745329
IDBP-746295
IDBP-745195
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20933442
RAB11A is an important regulator of Toll-like receptor 4 (TLR4) and TRAM transport to E. coli phagosomes thereby controlling IRF3 activation from this compartment.
Entrez Gene
Summary The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:65726054-65891991
Strand Forward strand
Band q22.31
Transcripts
ENST00000261890 ENSP00000261890
ENST00000569896 ENSP00000456420
ENST00000567671 ENSP00000454673
ENST00000569304
ENST00000565075 ENSP00000456638
ENST00000568850
ENST00000566233 ENSP00000454381
ENST00000564910 ENSP00000455567
ENST00000563580
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 65 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019905 syntaxin binding
Biological Process
GO:0000910 cytokinesis
GO:0006184 GTP catabolic process
GO:0006833 water transport
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0031175 neuron projection development
GO:0032402 melanosome transport
GO:0045087 innate immune response (InnateDB)
GO:0045773 positive regulation of axon extension
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048227 plasma membrane to endosome transport
GO:0051223 regulation of protein transport
GO:0055085 transmembrane transport
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030133 transport vesicle
GO:0030424 axon
GO:0030659 cytoplasmic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0032154 cleavage furrow
GO:0043234 protein complex
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004771
View Gene Order
ENSBTAG00000018959
Not yet available
Pathways
NETPATH
REACTOME
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
hsa04972
Pancreatic secretion pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
arf6downstreampathway
Arf6 downstream pathway
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL B4DQU5 H3BN38
UniProt Splice Variant
Entrez Gene 8766
UniGene Hs.321541 Hs.595057 Hs.619094 Hs.737314
RefSeq NM_001206836 NM_004663
HUGO HGNC:9760
OMIM 605570
CCDS CCDS10212 CCDS58373
HPRD 05715
IMGT
EMBL AC011939 AC084854 AK298961
GenPept BAG61057
RNA Seq Atlas 8766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca