InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rab11a

Summary

InnateDB Gene

IDBG-176597.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab11a

Gene Name

RAB11a, member RAS oncogene family

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004771

Encoded Proteins

IDBP-176599

RAB11a, member RAS oncogene family

IDBP-621257

RAB11a, member RAS oncogene family

IDBP-621258

RAB11a, member RAS oncogene family

IDBP-621261

RAB11a, member RAS oncogene family

IDBP-621262

RAB11a, member RAS oncogene family

IDBP-621263

RAB11a, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20933442

[Homo sapiens] RAB11A is an important regulator of Toll-like receptor 4 (TLR4) and TRAM transport to E. coli phagosomes thereby controlling IRF3 activation from this compartment.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103769:
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:64715299-64737758

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004892	ENSMUSP00000004892
ENSMUST00000172298	ENSMUSP00000129163
ENSMUST00000167569	ENSMUSP00000125755
ENSMUST00000172444
ENSMUST00000168366	ENSMUSP00000128150
ENSMUST00000166857
ENSMUST00000171100	ENSMUSP00000127968
ENSMUST00000169058	ENSMUSP00000129729
ENSMUST00000165083

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000910	cytokinesis
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0031175	neuron projection development
GO:0032402	melanosome transport
GO:0045773	positive regulation of axon extension
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0051223	regulation of protein transport
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0030424	axon
GO:0030670	phagocytic vesicle membrane
GO:0032154	cleavage furrow
GO:0043234	protein complex
GO:0045335	phagocytic vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome