InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: A2M

Summary

InnateDB Gene

IDBG-17623.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

A2M

Gene Name

alpha-2-macroglobulin

Synonyms

A2MD; CPAMD5; FWP007; S863-7

Species

Homo sapiens

Ensembl Gene

ENSG00000175899

Encoded Proteins

IDBP-17625

alpha-2-macroglobulin

IDBP-295008

alpha-2-macroglobulin

IDBP-594892

alpha-2-macroglobulin

IDBP-586522

alpha-2-macroglobulin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:9067664-9116229

Strand

Reverse strand

Band

p13.31

Transcripts

ENST00000318602	ENSP00000323929
ENST00000404455	ENSP00000385710
ENST00000495442
ENST00000495709
ENST00000462568
ENST00000472360
ENST00000467091
ENST00000497324
ENST00000543436
ENST00000545828
ENST00000542567
ENST00000546069	ENSP00000438599
ENST00000539638	ENSP00000445717

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 138 experimentally validated interaction(s) in this database.

Experimentally validated
Total	138 [view]
Protein-Protein	138 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0019838	growth factor binding
GO:0019899	enzyme binding
GO:0019959	interleukin-8 binding
GO:0019966	interleukin-1 binding
GO:0043120	tumor necrosis factor binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001869	negative regulation of complement activation, lectin pathway
GO:0002576	platelet degranulation
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0010951	negative regulation of endopeptidase activity
GO:0022617	extracellular matrix disassembly
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0048863	stem cell differentiation
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle