Version 5.4
Homo sapiens Gene: PKP3
Summary
InnateDB Gene IDBG-16380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKP3
Gene Name plakophilin 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184363
Encoded Proteins
IDBP-16384
plakophilin 3
IDBP-586811
plakophilin 3
IDBP-598951
plakophilin 3
IDBP-602816
plakophilin 3
IDBP-602786
plakophilin 3
IDBP-602160
plakophilin 3
IDBP-587355
plakophilin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:392614-404908
Strand Forward strand
Band p15.5
Transcripts
ENST00000331563 ENSP00000331678
ENST00000534401 ENSP00000434517
ENST00000533249 ENSP00000435383
ENST00000527442 ENSP00000435522
ENST00000528036 ENSP00000434110
ENST00000533069
ENST00000531857 ENSP00000435478
ENST00000530695
ENST00000524646
ENST00000526971
ENST00000525642 ENSP00000436847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002159 desmosome assembly
GO:0016337 single organismal cell-cell adhesion
GO:0090002 establishment of protein localization to plasma membrane
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0030057 desmosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054065
View Gene Order
ENSBTAG00000048098
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Y446
TrEMBL E9PJR7 E9PKC4 E9PQ15 E9PRW6
UniProt Splice Variant
Entrez Gene 11187
UniGene Hs.534395
RefSeq NM_007183 XM_005252760
HUGO HGNC:9025
OMIM 605561
CCDS CCDS7695
HPRD 05711
IMGT
EMBL AC138230 AF053719 AK223511 BC000081 DA439471 FN421477 Z98265
GenPept AAF23050 AAH00081 BAD97231 CAB44310 CAZ65731
RNA Seq Atlas 11187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca