Bos taurus Gene: BT.34208
InnateDB Gene IDBG-639986.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.34208
Gene Name C5a anaphylatoxin chemotactic receptor
Synonyms C5R1
Species Bos taurus
Ensembl Gene ENSBTAG00000020872
Encoded Proteins
C5a anaphylatoxin chemotactic receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
[Homo sapiens] C5AR1 engage in crosstalk with TLR2 and Porphyromonas gingivalis, a major oral and systemic pathogen with complement C5 convertase-like activity, synergizes with C5a (fragment of complement protein C5) to increase cyclic adenosine monophosphate (cAMP) concentrations, resulting in suppression of macrophage immune function and enhanced pathogen survival.
[Homo sapiens] C5AR1 is a receptor for C5a, a chief component of complement activation produced via all three complement pathways (i.e., lectin, classical, and alternative), stimulated tissue-resident macrophages, but not dendritic cells, to produce inflammatory cytokines including IL-6, in synergy with Toll-like receptor signalling or, notably, granulocyte/macrophage colony-stimulating factor (GM-CSF).
[Homo sapiens] Increasing circulating C5AR1 serum concentration, coupled with decreased C5AR1 expression on neutrophils is correlated with lethality from septic shock.
[Homo sapiens] Staphylococcus aureus-induced neutrophil dysfunction correlates with the loss of C5AR1 from the neutrophil cell surface and results in C5a (C5)-induced CEACAM8 overexpression.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197405:
Gene Information
Type Protein coding
Genomic Location Chromosome 18:54753334-54767002
Strand Forward strand
ENSBTAT00000027807 ENSBTAP00000027807
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004878 complement component C5a receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004942 anaphylatoxin receptor activity
GO:0004944 C5a anaphylatoxin receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0030593 neutrophil chemotaxis
GO:0032494 response to peptidoglycan
GO:0038178 complement component C5a signaling pathway
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050830 defense response to Gram-positive bacterium
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0045177 apical part of cell
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
G alpha (i) signalling events pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Neuroactive ligand-receptor interaction pathway
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
Neuroactive ligand-receptor interaction pathway
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
TrEMBL Q673L2 Q866B1
UniProt Splice Variant
Entrez Gene 493645
UniGene Bt.34208
RefSeq NM_001007810 XM_005195369 XM_005219180
EMBL AY540054 DAAA02047414 X65861
GenPept AAT09991 CAA46691
RNA Seq Atlas 101908388 493645