InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.34208

Summary

InnateDB Gene

IDBG-639986.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.34208

Gene Name

C5a anaphylatoxin chemotactic receptor

Synonyms

C5R1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020872

Encoded Proteins

IDBP-692183

C5a anaphylatoxin chemotactic receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20159852

[Homo sapiens] C5AR1 engage in crosstalk with TLR2 and Porphyromonas gingivalis, a major oral and systemic pathogen with complement C5 convertase-like activity, synergizes with C5a (fragment of complement protein C5) to increase cyclic adenosine monophosphate (cAMP) concentrations, resulting in suppression of macrophage immune function and enhanced pathogen survival.

PMID 20457757

[Homo sapiens] C5AR1 is a receptor for C5a, a chief component of complement activation produced via all three complement pathways (i.e., lectin, classical, and alternative), stimulated tissue-resident macrophages, but not dendritic cells, to produce inflammatory cytokines including IL-6, in synergy with Toll-like receptor signalling or, notably, granulocyte/macrophage colony-stimulating factor (GM-CSF).

PMID 23479227

[Homo sapiens] Increasing circulating C5AR1 serum concentration, coupled with decreased C5AR1 expression on neutrophils is correlated with lethality from septic shock.

PMID 26176669

[Homo sapiens] Staphylococcus aureus-induced neutrophil dysfunction correlates with the loss of C5AR1 from the neutrophil cell surface and results in C5a (C5)-induced CEACAM8 overexpression.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197405:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:54753334-54767002

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027807

ENSBTAP00000027807

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004878	complement component C5a receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004942	anaphylatoxin receptor activity
GO:0004944	C5a anaphylatoxin receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030593	neutrophil chemotaxis
GO:0032494	response to peptidoglycan
GO:0038178	complement component C5a signaling pathway
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050830	defense response to Gram-positive bacterium
GO:0070374	positive regulation of ERK1 and ERK2 cascade