Version 5.4
Homo sapiens Gene: C5AR1
Summary
InnateDB Gene IDBG-59445.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C5AR1
Gene Name complement component 5a receptor 1
Synonyms C5A; C5AR; C5R1; CD88
Species Homo sapiens
Ensembl Gene ENSG00000197405
Encoded Proteins
IDBP-59447
complement component 5a receptor 1
IDBP-765589
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20159852
C5AR1 engage in crosstalk with TLR2 and Porphyromonas gingivalis, a major oral and systemic pathogen with complement C5 convertase-like activity, synergizes with C5a (fragment of complement protein C5) to increase cyclic adenosine monophosphate (cAMP) concentrations, resulting in suppression of macrophage immune function and enhanced pathogen survival.
PMID 20457757
C5AR1 is a receptor for C5a, a chief component of complement activation produced via all three complement pathways (i.e., lectin, classical, and alternative), stimulated tissue-resident macrophages, but not dendritic cells, to produce inflammatory cytokines including IL-6, in synergy with Toll-like receptor signalling or, notably, granulocyte/macrophage colony-stimulating factor (GM-CSF).
PMID 23479227
Increasing circulating C5AR1 serum concentration, coupled with decreased C5AR1 expression on neutrophils is correlated with lethality from septic shock.
PMID 26176669
Staphylococcus aureus-induced neutrophil dysfunction correlates with the loss of C5AR1 from the neutrophil cell surface and results in C5a (C5)-induced CEACAM8 overexpression.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47290023-47322066
Strand Forward strand
Band q13.32
Transcripts
ENST00000355085 ENSP00000347197
ENST00000594787 ENSP00000470613
ENST00000595501
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001856 complement component C5a binding
GO:0004878 complement component C5a receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004944 C5a anaphylatoxin receptor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0002430 complement receptor mediated signaling pathway
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007606 sensory perception of chemical stimulus
GO:0021534 cell proliferation in hindbrain
GO:0030593 neutrophil chemotaxis
GO:0031100 organ regeneration
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0038178 complement component C5a signaling pathway
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050830 defense response to Gram-positive bacterium
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049130
View Gene Order
ENSBTAG00000020872
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04610
Complement and coagulation cascades pathway
hsa05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Cross-References
SwissProt P21730
TrEMBL
UniProt Splice Variant
Entrez Gene 728
UniGene Hs.2161
RefSeq NM_001736 XM_005259190
HUGO HGNC:1338
OMIM 113995
CCDS CCDS33063
HPRD
IMGT
EMBL AC099491 AY221091 BC008982 BT007358 M62505 S56556 S56557 X57250 X58674
GenPept AAA62831 AAD14919 AAH08982 AAO65969 AAP36022 CAA40530 CAB37830
RNA Seq Atlas 728

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca