InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.27525

Summary

InnateDB Protein

IDBP-696826.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.27525

Protein Name

mitogen-activated protein kinase kinase kinase 11

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005378

InnateDB Gene

IDBG-644205 (BT.27525)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000080	mitotic G1 phase
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007017	microtubule-based process
GO:0007257	activation of JUN kinase activity
GO:0008283	cell proliferation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043507	positive regulation of JUN kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005813	centrosome
GO:0005874	microtubule
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00018
PF14604
PF07653

PRINTS

PR00109
PR00452

PIRSF

SMART

SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt