InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.27525

Summary

InnateDB Gene

IDBG-644205.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.27525

Gene Name

mitogen-activated protein kinase kinase kinase 11

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004114

Encoded Proteins

IDBP-696826

mitogen-activated protein kinase kinase kinase 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173327:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:44444057-44460617

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005378

ENSBTAP00000005378

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000080	mitotic G1 phase
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007017	microtubule-based process
GO:0007257	activation of JUN kinase activity
GO:0008283	cell proliferation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043507	positive regulation of JUN kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation