InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scube1

Summary

InnateDB Protein

IDBP-623534.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scube1

Protein Name

signal peptide, CUB domain, EGF-like 1

Synonyms

7330410C13Rik; A630023E24Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130131

InnateDB Gene

IDBG-168528 (Scube1)

Protein Structure

UniProt Annotation

Function

Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. {ECO:0000250}.

Subcellular Localization

Secreted. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0051260

protein homooligomerization

Cellular Component

GO:0005615	extracellular space
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0019897	extrinsic component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:1890616

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

PFAM

PF00008
PF00431
PF07645
PF07699

PRINTS

PIRSF

SMART

SM00181
SM00042
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6NZL8