InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFKBIA

Summary

InnateDB Protein

IDBP-4760.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFKBIA

Protein Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Synonyms

IKBA; MAD-3; NFKBI;

Species

Homo sapiens

Ensembl Protein

ENSP00000216797

InnateDB Gene

IDBG-4758 (NFKBIA)

Protein Structure

UniProt Annotation

Function

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269PubMed:7479976}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}.

Disease Associations

Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant (ADEDAID) [MIM:612132]: A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection. {ECO:0000269PubMed:14523047, ECO:0000269PubMed:18412279}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 234 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	234 [view]
Protein-Protein	210 [view]
Protein-DNA	23 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008139	nuclear localization sequence binding
GO:0019899	enzyme binding
GO:0031072	heat shock protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006915	apoptotic process
GO:0007253	cytoplasmic sequestering of NF-kappaB
GO:0010468	regulation of gene expression
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010875	positive regulation of cholesterol efflux
GO:0010888	negative regulation of lipid storage
GO:0016032	viral process
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032481	positive regulation of type I interferon production
GO:0032495	response to muramyl dipeptide
GO:0032496	response to lipopolysaccharide
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042345	regulation of NF-kappaB import into nucleus
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0043066	negative regulation of apoptotic process
GO:0043330	response to exogenous dsRNA
GO:0043392	negative regulation of DNA binding
GO:0045087	innate immune response (InnateDB)
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050852	T cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070417	cellular response to cold
GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway