Homo sapiens Gene: NFKBIA
InnateDB Gene IDBG-4758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKBIA
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Synonyms IKBA; MAD-3; NFKBI;
Species Homo sapiens
Ensembl Gene ENSG00000100906
Encoded Proteins
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:35401511-35404749
Strand Reverse strand
Band q13.2
ENST00000216797 ENSP00000216797
ENST00000554001 ENSP00000450537
ENST00000557140 ENSP00000451257
ENST00000557389 ENSP00000450514
ENST00000553342 ENSP00000451281
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Experimentally validated
Total 234 [view]
Protein-Protein 210 [view]
Protein-DNA 23 [view]
Protein-RNA 0
DNA-DNA 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008139 nuclear localization sequence binding
GO:0019899 enzyme binding
GO:0031072 heat shock protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006915 apoptotic process
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0010468 regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010888 negative regulation of lipid storage
GO:0016032 viral process
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032481 positive regulation of type I interferon production
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042345 regulation of NF-kappaB import into nucleus
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043066 negative regulation of apoptotic process
GO:0043330 response to exogenous dsRNA
GO:0043392 negative regulation of DNA binding
GO:0045087 innate immune response (InnateDB)
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070417 cellular response to cold
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0033256 I-kappaB/NF-kappaB complex
GO:0043234 protein complex
No orthologs found for this gene
UniProt Splice Variant
Entrez Gene 4792
RefSeq NM_020529
OMIM 164008
HPRD 01235
EMBL AJ249290 AL133163
GenPept CAB65113
RNA Seq Atlas 4792