InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndn

Summary

InnateDB Protein

IDBP-190589.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndn

Protein Name

necdin

Synonyms

AI528698; Peg6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045369

InnateDB Gene

IDBG-190587 (Ndn)

Protein Structure

UniProt Annotation

Function

Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10965153}. Nucleus, nucleoplasm {ECO:0000269PubMed:10965153}. Nucleus matrix {ECO:0000269PubMed:10965153}. Note=Mainly cytoplasmic. Translocates to the nucleus where it is found associated with the nuclear matrix.

Disease Associations

Tissue Specificity

Brain specific. Not detected in other tissues. Expressed in postmitotic neurons. In adult brain the highest expression is in hypothalamus. Highly expressed in thalamus and midbrain. Relatively low levels are in cerebral cortex, hippocampus, striatum, olfactory bulb, cerebellum, pons and spinal cord. Also detected in neurally differentiated embryonal carcinoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	89 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001764	neuron migration
GO:0003016	respiratory system process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006874	cellular calcium ion homeostasis
GO:0007409	axonogenesis
GO:0007413	axonal fasciculation
GO:0007417	central nervous system development
GO:0007585	respiratory gaseous exchange
GO:0008347	glial cell migration
GO:0009791	post-embryonic development
GO:0019233	sensory perception of pain
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048666	neuron development
GO:0048675	axon extension
GO:0048871	multicellular organismal homeostasis
GO:0071514	genetic imprinting