Version 5.4
Mus musculus Gene: Ndn
Summary
InnateDB Gene IDBG-190587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndn
Gene Name necdin
Synonyms AI528698; Peg6
Species Mus musculus
Ensembl Gene ENSMUSG00000033585
Encoded Proteins
IDBP-190589
necdin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182636:
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:62348277-62349928
Strand Forward strand
Band C
Transcripts
ENSMUST00000038775 ENSMUSP00000045369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 93 [view]
Protein-Protein 89 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0043015 gamma-tubulin binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001764 neuron migration
GO:0003016 respiratory system process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006874 cellular calcium ion homeostasis
GO:0007409 axonogenesis
GO:0007413 axonal fasciculation
GO:0007417 central nervous system development
GO:0007585 respiratory gaseous exchange
GO:0008347 glial cell migration
GO:0009791 post-embryonic development
GO:0019233 sensory perception of pain
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048666 neuron development
GO:0048675 axon extension
GO:0048871 multicellular organismal homeostasis
GO:0071514 genetic imprinting
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000182636
View Gene Order
ENSBTAG00000002186
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt P25233
TrEMBL
UniProt Splice Variant
Entrez Gene 17984
UniGene Mm.400253
RefSeq NM_010882
OMIM
CCDS CCDS21326
HPRD
IMGT
MGI ID MGI:97290
MGI Symbol Ndn
EMBL AK005078 AK075729 AK075735 AK076025 AK135444 AK149086 BC147249 BC147250 D76440 M80840
GenPept AAA39805 AAI47250 AAI47251 BAA11183 BAB23802 BAC35914 BAC35917 BAC36130 BAE22535 BAE28734
RNA Seq Atlas 17984

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca