InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lmcd1

Summary

InnateDB Protein

IDBP-174857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmcd1

Protein Name

LIM and cysteine-rich domains 1

Synonyms

AW455500; AW553074; dyxin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032376

InnateDB Gene

IDBG-174855 (Lmcd1)

Protein Structure

UniProt Annotation

Function

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000269PubMed:16199866, ECO:0000269PubMed:20026769}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16199866}. Nucleus {ECO:0000269PubMed:16199866}. Note=May shuttle between the cytoplasm and the nucleus.

Disease Associations

Tissue Specificity

Expressed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium. {ECO:0000269PubMed:16199866}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0010611	regulation of cardiac muscle hypertrophy
GO:0070886	positive regulation of calcineurin-NFAT signaling cascade