InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: C2

Summary

InnateDB Protein

IDBP-174634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

complement component 2 (within H-2S)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025230

InnateDB Gene

IDBG-174547 (C2)

Protein Structure

UniProt Annotation

Function

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0006955	immune response
GO:0006956	complement activation
GO:0006958	complement activation, classical pathway
GO:0007584	response to nutrient
GO:0045087	innate immune response
GO:2000427	positive regulation of apoptotic cell clearance

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:88226

InterPro

IPR000436 Sushi/SCR/CCP
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002035 von Willebrand factor, type A
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR011360 Complement B/C2

PFAM

PF00084
PF00089
PF00092

PRINTS

PR00722

PIRSF

PIRSF001154

SMART

SM00032
SM00020
SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References