InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: C2

Summary

InnateDB Gene

IDBG-174547.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

complement component 2 (within H-2S)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024371

Encoded Proteins

IDBP-174634

complement component 2 (within H-2S)

IDBP-541867

complement component 2 (within H-2S)

IDBP-534338

complement component 2 (within H-2S)

IDBP-537675

complement component 2 (within H-2S)

IDBP-714117

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25381436

[Homo sapiens] Staphylococcus aureus extracellular adherence protein (Eap) binds to C4B to inhibit binding of both full-length C2 and its C2b fragment, disrupting the formation of the C3 proconvertase (C4b2) and significantly diminishing the extent of S. aureus opsonophagocytosis and killing by neutrophils.

PMID 26608922

[Homo sapiens] Complement interfering protein (CIP) of group B Streptococcus (GBS) shows high affinity toward C4B and inhibits its interaction with C2, presumably preventing the formation of the C4BC2A convertase and GBS phagocytic killing in the absence of anti-GBS antibodies.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166278:
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34862604-34898265

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025230	ENSMUSP00000025230
ENSMUST00000152417	ENSMUSP00000123536
ENSMUST00000148431	ENSMUSP00000120009
ENSMUST00000134300	ENSMUSP00000114241
ENSMUST00000127795
ENSMUST00000130728
ENSMUST00000174880
ENSMUST00000174279
ENSMUST00000176332	ENSMUSP00000135304

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006956	complement activation
GO:0006958	complement activation, classical pathway
GO:0007584	response to nutrient
GO:0045087	innate immune response
GO:2000427	positive regulation of apoptotic cell clearance