Version 5.4
Mus musculus Protein: Msra
Summary
InnateDB Protein IDBP-173260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msra
Protein Name methionine sulfoxide reductase A
Synonyms 2310045J23Rik; 6530413P12Rik; MSR-A;
Species Mus musculus
Ensembl Protein ENSMUSP00000065754
InnateDB Gene IDBG-173258 (Msra)
Protein Structure
UniProt Annotation
Function Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). {ECO:0000250}.
Subcellular Localization Isoform 1: Mitochondrion.Isoform 2: Cytoplasm. Nucleus. Membrane; Lipid-anchor.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008113 peptide-methionine (S)-S-oxide reductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0030091 protein repair
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:106916
InterPro IPR002569 Peptide methionine sulphoxide reductase MsrA
PFAM PF01625
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D6Y7
PhosphoSite PhosphoSite-Q9D6Y7
TrEMBL
UniProt Splice Variant
Entrez Gene 110265
UniGene Mm.490145
RefSeq NP_080598
MGI ID 2L90
MGI Symbol Msra
OMIM
CCDS CCDS27209
HPRD
IMGT
EMBL AK002356 AK009822 AK018338 AK049714 BC014738 BC089311 CH466535
GenPept AAH14738 AAH89311 BAB22035 BAB26522 BAC33889 EDL36048

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca