Version 5.4
Mus musculus Gene: Msra
Summary
InnateDB Gene IDBG-173258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msra
Gene Name methionine sulfoxide reductase A
Synonyms 2310045J23Rik; 6530413P12Rik; MSR-A
Species Mus musculus
Ensembl Gene ENSMUSG00000054733
Encoded Proteins
IDBP-173260
methionine sulfoxide reductase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175806:
This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:64122623-64455903
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000067927 ENSMUSP00000065754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008113 peptide-methionine (S)-S-oxide reductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0030091 protein repair
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000175806
View Gene Order
ENSBTAG00000021632
Not yet available
Cross-References
SwissProt Q9D6Y7
TrEMBL
UniProt Splice Variant
Entrez Gene 110265
UniGene Mm.26713 Mm.490145
RefSeq NM_001253712 NM_001253714 NM_001253715 NM_001253716 NM_026322 XM_006518428
OMIM
CCDS CCDS27209
HPRD
IMGT
MGI ID MGI:106916
MGI Symbol Msra
EMBL AK002356 AK009822 AK018338 AK049714 BC014738 BC089311 CH466535
GenPept AAH14738 AAH89311 BAB22035 BAB26522 BAC33889 EDL36048
RNA Seq Atlas 110265

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca