InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VAPA

Summary

InnateDB Gene

IDBG-869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAPA

Gene Name

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

Synonyms

hVAP-33; VAP-33; VAP-A; VAP33

Species

Homo sapiens

Ensembl Gene

ENSG00000101558

Encoded Proteins

IDBP-871

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

IDBP-229268

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

IDBP-725905

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:9914002-9960021

Strand

Forward strand

Band

p11.22

Transcripts

ENST00000340541	ENSP00000345656
ENST00000400000	ENSP00000382880
ENST00000583475
ENST00000577901
ENST00000584796
ENST00000583879
ENST00000578314
ENST00000577539
ENST00000585042	ENSP00000463155

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	64 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0007165	signal transduction
GO:0008219	cell death
GO:0030148	sphingolipid biosynthetic process
GO:0031175	neuron projection development
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281	small molecule metabolic process
GO:0061025	membrane fusion
GO:0070972	protein localization to endoplasmic reticulum

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0015630	microtubule cytoskeleton
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024091

View Gene Order

ENSBTAG00000017279

Not yet available

Pathways

NETPATH

REACTOME

REACT_115810

Sphingolipid de novo biosynthesis pathway

REACT_19323

Sphingolipid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa04530

Tight junction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.165195 Hs.595023 Hs.723672

RefSeq

NM_003574 NM_194434

HUGO

OMIM

CCDS

CCDS11847 CCDS11848

HPRD

09299

IMGT

EMBL

GenPept

RNA Seq Atlas