InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAPA

Summary

InnateDB Protein

IDBP-871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAPA

Protein Name

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

Synonyms

hVAP-33; VAP-33; VAP-A; VAP33;

Species

Homo sapiens

Ensembl Protein

ENSP00000345656

InnateDB Gene

IDBG-869 (VAPA)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle trafficking. {ECO:0000269PubMed:11511104, ECO:0000269PubMed:19289470}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10523508, ECO:0000269PubMed:19289470}; Single-pass type IV membrane protein {ECO:0000269PubMed:10523508, ECO:0000269PubMed:19289470}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	64 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0007165	signal transduction
GO:0008219	cell death
GO:0030148	sphingolipid biosynthetic process
GO:0031175	neuron projection development
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281	small molecule metabolic process
GO:0061025	membrane fusion
GO:0070972	protein localization to endoplasmic reticulum

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0015630	microtubule cytoskeleton
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0048471	perinuclear region of cytoplasm