Version 5.4
Homo sapiens Gene: CFL2
Summary
InnateDB Gene IDBG-4594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFL2
Gene Name cofilin 2 (muscle)
Synonyms NEM7
Species Homo sapiens
Ensembl Gene ENSG00000165410
Encoded Proteins
IDBP-4596
cofilin 2 (muscle)
IDBP-4598
cofilin 2 (muscle)
IDBP-365639
cofilin 2 (muscle)
IDBP-597441
cofilin 2 (muscle)
IDBP-602193
cofilin 2 (muscle)
IDBP-591252
cofilin 2 (muscle)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:34706769-34714823
Strand Reverse strand
Band q13.1
Transcripts
ENST00000298159 ENSP00000298159
ENST00000341223 ENSP00000340635
ENST00000422678 ENSP00000409326
ENST00000554470 ENSP00000450862
ENST00000555765 ENSP00000452451
ENST00000556161 ENSP00000452188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007015 actin filament organization
GO:0030042 actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
GO:0045214 sarcomere organization
GO:0046716 muscle cell cellular homeostasis
GO:0061001 regulation of dendritic spine morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0015629 actin cytoskeleton
GO:0016363 nuclear matrix
GO:0031674 I band
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062929
View Gene Order
ENSBTAG00000015053
Not yet available
Pathways
NETPATH
NetPath_22
Leptin pathway
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04360
Axon guidance pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt
TrEMBL F8WDN3
UniProt Splice Variant
Entrez Gene 1073
UniGene Hs.180141 Hs.592316
RefSeq NM_001243645 NM_021914 NM_138638
HUGO HGNC:1875
OMIM 601443
CCDS CCDS58311 CCDS9649 CCDS9650
HPRD 03262
IMGT
EMBL AL355885
GenPept
RNA Seq Atlas 1073

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca