Version 5.4
Bos taurus Gene: CFL2
Summary
InnateDB Gene IDBG-632476.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFL2
Gene Name Cofilin-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015053
Encoded Proteins
IDBP-684097
Cofilin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165410:
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:45519654-45522305
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020036 ENSBTAP00000020036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007015 actin filament organization
GO:0030042 actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
GO:0045214 sarcomere organization
GO:0046716 muscle cell cellular homeostasis
GO:0061001 regulation of dendritic spine morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0016363 nuclear matrix
GO:0031674 I band
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165410
View Gene Order
ENSMUSG00000062929
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_22
Leptin pathway
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04360
Axon guidance pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
mmu04360
Axon guidance pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt Q148F1
TrEMBL
UniProt Splice Variant
Entrez Gene 539332
UniGene Bt.15839 Bt.97433
RefSeq NM_001076154 XM_005222049
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118390
GenPept AAI18391
RNA Seq Atlas 539332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca