Version 5.4
Homo sapiens Gene: NDN
Summary
InnateDB Gene IDBG-4155.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDN
Gene Name necdin homolog (mouse)
Synonyms HsT16328; PWCR
Species Homo sapiens
Ensembl Gene ENSG00000182636
Encoded Proteins
IDBP-4157
necdin homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:23685400-23687330
Strand Reverse strand
Band q11.2
Transcripts
ENST00000331837 ENSP00000332643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 65 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 73 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0043015 gamma-tubulin binding
Biological Process
GO:0001764 neuron migration
GO:0003016 respiratory system process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0007413 axonal fasciculation
GO:0007417 central nervous system development
GO:0007585 respiratory gaseous exchange
GO:0008285 negative regulation of cell proliferation
GO:0008347 glial cell migration
GO:0009791 post-embryonic development
GO:0019233 sensory perception of pain
GO:0040008 regulation of growth
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048666 neuron development
GO:0048675 axon extension
GO:0048871 multicellular organismal homeostasis
GO:0071514 genetic imprinting
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0042995 cell projection
GO:0043204 perikaryon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033585
View Gene Order
ENSBTAG00000002186
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt Q99608
TrEMBL X5D982
UniProt Splice Variant
Entrez Gene 4692
UniGene Hs.50130 Hs.599307
RefSeq NM_002487
HUGO HGNC:7675
OMIM 602117
CCDS CCDS10014
HPRD
IMGT
EMBL AB007828 AK312779 BC008750 KJ534888 U35139
GenPept AAB39469 AAH08750 AHW56528 BAA22660 BAG35642
RNA Seq Atlas 4692

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca