Version 5.4
Homo sapiens Gene: MTIF3
Summary
InnateDB Gene IDBG-19204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTIF3
Gene Name mitochondrial translational initiation factor 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122033
Encoded Proteins
IDBP-19206
mitochondrial translational initiation factor 3
IDBP-19208
mitochondrial translational initiation factor 3
IDBP-292586
mitochondrial translational initiation factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:27435643-27450591
Strand Reverse strand
Band q12.2
Transcripts
ENST00000381120 ENSP00000370512
ENST00000381116 ENSP00000370508
ENST00000405591 ENSP00000384659
ENST00000461838
ENST00000460973
ENST00000471771
ENST00000493719
ENST00000485650
ENST00000484342
ENST00000485959
ENST00000483903
ENST00000464753
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0008135 translation factor activity, nucleic acid binding
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0001732 formation of translation initiation complex
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016510
View Gene Order
ENSBTAG00000020530
Not yet available
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267680
Mitochondrial translation initiation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9H2K0
TrEMBL
UniProt Splice Variant
Entrez Gene 219402
UniGene
RefSeq NM_001166261 NM_001166262 NM_001166263 NM_152912 XM_005266283 XM_006719771 XM_006719772
HUGO HGNC:29788
OMIM
CCDS CCDS9322
HPRD
IMGT
EMBL AF265440 AF410851 AL137059 BC039599 BC046166
GenPept AAG44698 AAH39599 AAH46166 AAL04150 CAH70316
RNA Seq Atlas 219402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca