InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTIF3

Summary

InnateDB Protein

IDBP-292586.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTIF3

Protein Name

mitochondrial translational initiation factor 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384659

InnateDB Gene

IDBG-19204 (MTIF3)

Protein Structure

UniProt Annotation

Function

IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. {ECO:0000269PubMed:12095986}.

Subcellular Localization

Mitochondrion {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0008135	translation factor activity, nucleic acid binding
GO:0043024	ribosomal small subunit binding

Biological Process

GO:0001732	formation of translation initiation complex
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0032790	ribosome disassembly