Version 5.4
Homo sapiens Gene: MADCAM1
Summary
InnateDB Gene IDBG-12208.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MADCAM1
Gene Name mucosal vascular addressin cell adhesion molecule 1
Synonyms MACAM1
Species Homo sapiens
Ensembl Gene ENSG00000099866
Encoded Proteins
IDBP-12214
mucosal vascular addressin cell adhesion molecule 1
IDBP-12216
mucosal vascular addressin cell adhesion molecule 1
IDBP-12218
mucosal vascular addressin cell adhesion molecule 1
IDBP-813346
mucosal vascular addressin cell adhesion molecule 1
IDBP-813351
mucosal vascular addressin cell adhesion molecule 1
IDBP-813354
mucosal vascular addressin cell adhesion molecule 1
IDBP-813355
mucosal vascular addressin cell adhesion molecule 1
IDBP-813357
mucosal vascular addressin cell adhesion molecule 1
IDBP-813358
mucosal vascular addressin cell adhesion molecule 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:489176-505343
Strand Forward strand
Band p13.3
Transcripts
ENST00000215637 ENSP00000215637
ENST00000346144 ENSP00000304247
ENST00000382683 ENSP00000372130
ENST00000587541 ENSP00000475575
ENST00000622449
ENST00000621286 ENSP00000483663
ENST00000619333 ENSP00000484153
ENST00000613880 ENSP00000480908
ENST00000622462 ENSP00000480104
ENST00000617201 ENSP00000484317
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002687 positive regulation of leukocyte migration
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007568 aging
GO:0030198 extracellular matrix organization
GO:0030216 keratinocyte differentiation
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020310
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
a4b7_pathway
a4b7 Integrin signaling
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8174
UniGene
RefSeq NM_130760 NM_130762
HUGO HGNC:6765
OMIM 102670
CCDS CCDS12028 CCDS12029
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 8174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca