Version 5.4
Mus musculus Gene: Madcam1
Summary
InnateDB Gene IDBG-170375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Madcam1
Gene Name mucosal vascular addressin cell adhesion molecule 1
Synonyms AV211525
Species Mus musculus
Ensembl Gene ENSMUSG00000020310
Encoded Proteins
IDBP-170377
mucosal vascular addressin cell adhesion molecule 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099866:
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:79664574-79668536
Strand Forward strand
Band C1
Transcripts
ENSMUST00000020554 ENSMUSP00000020554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002687 positive regulation of leukocyte migration
GO:0007155 cell adhesion
GO:0007568 aging
GO:0009790 embryo development
GO:0030216 keratinocyte differentiation
GO:0050900 leukocyte migration
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000099866
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
a4b7_pathway
a4b7 Integrin signaling
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL G5E838
UniProt Splice Variant
Entrez Gene 17123
UniGene Mm.391556
RefSeq NM_013591
OMIM
CCDS CCDS23981
HPRD
IMGT
MGI ID MGI:103579
MGI Symbol Madcam1
EMBL AC132265 CH466553
GenPept EDL31682
RNA Seq Atlas 17123

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca