Homo sapiens Gene: PLA2G2A
Summary
InnateDB Gene IDBG-92794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G2A
Gene Name phospholipase A2, group IIA (platelets, synovial fluid)
Synonyms MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2;
Species Homo sapiens
Ensembl Gene ENSG00000188257
Encoded Proteins
phospholipase A2, group IIA (platelets, synovial fluid)
phospholipase A2, group IIA (platelets, synovial fluid)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL22 induced at an early stage of L. monocytogenes infection enhances innate immunity against L. monocytogenes in the liver by stimulating hepatocytes to produce an antimicrobial molecule, PLA2G2A
Entrez Gene
Summary The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5\' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:19975431-19980416
Strand Reverse strand
Band p36.13
Transcripts
ENST00000375111 ENSP00000364252
ENST00000400520 ENSP00000383364
ENST00000469162
ENST00000496748
ENST00000491964
ENST00000482011
ENST00000461140
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0008285 negative regulation of cell proliferation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0016042 lipid catabolic process
GO:0034374 low-density lipoprotein particle remodeling
GO:0035019 somatic stem cell maintenance
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0042127 regulation of cell proliferation
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046473 phosphatidic acid metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0030141 secretory granule
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Acyl chain remodelling of PS pathway
Metabolism of lipids and lipoproteins pathway
Acyl chain remodelling of PC pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Metabolism pathway
Acyl chain remodelling of PI pathway
KEGG
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
alpha-Linolenic acid metabolism pathway
Vascular smooth muscle contraction pathway
Pancreatic secretion pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Glypican 1 network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000300 NM_001161727 NM_001161728 NM_001161729
HUGO
OMIM
CCDS CCDS201
HPRD 01397
IMGT
EMBL
GenPept
RNA Seq Atlas