InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G2A

Summary

InnateDB Protein

IDBP-92796.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G2A

Protein Name

phospholipase A2, group IIA (platelets, synovial fluid)

Synonyms

MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000364252

InnateDB Gene

IDBG-92794 (PLA2G2A)

Protein Structure

UniProt Annotation

Function

Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.

Subcellular Localization

Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding
GO:0005543	phospholipid binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0016042	lipid catabolic process
GO:0034374	low-density lipoprotein particle remodeling
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046473	phosphatidic acid metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050729	positive regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium