Mus musculus Gene: Atf3
Summary
InnateDB Gene IDBG-57018.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Atf3
Gene Name Cyclic AMP-dependent transcription factor ATF-3
Synonyms LRG-21
Species Mus musculus
Ensembl Gene ENSMUSG00000026628
Encoded Proteins
Cyclic AMP-dependent transcription factor ATF-3
Cyclic AMP-dependent transcription factor ATF-3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Atf3 has been identified as a high-density lipoprotein ??inducible negative regulator of macrophage activation.
Atf3 plays an important role in modulating IFN responses in macrophages by controlling basal and inducible levels of Ifnb1, as well as the expression of genes downstream of IFN signalling.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] ATF3 is induced by lipopolysaccharide (LPS) and regulates TLR-stimulated inflammatory responses as part of a negative-feedback loop.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162772:
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:191170296-191218039
Strand Reverse strand
Band H6
Transcripts
ENSMUST00000027941 ENSMUSP00000027941
ENSMUST00000131854
ENSMUST00000195117 ENSMUSP00000141492
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 0
Protein-DNA 25 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 73 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 DNA binding transcription factor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006094 gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034198 cellular response to amino acid starvation
GO:0035914 skeletal muscle cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:1990622 CHOP-ATF3 complex
Orthologs
Species
Bos taurus
Homo sapiens
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
HTLV-I infection pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
ID pathway
REACTOME
ATF4 activates genes pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
Unfolded Protein Response (UPR) pathway
KEGG
HTLV-I infection pathway
INOH
PID NCI
Direct p53 effectors
Regulation of nuclear SMAD2/3 signaling
AP-1 transcription factor network
ATF-2 transcription factor network
Cross-References
SwissProt Q60765
TrEMBL Q4FJW1
UniProt Splice Variant
Entrez Gene 11910
UniGene
RefSeq NM_007498
OMIM
CCDS CCDS15616
HPRD
IMGT
MGI ID MGI:109384
MGI Symbol Atf3
EMBL AB291912 AK133965 AK156786 BC019946 BC064799 CH466555 CT010291 U19118
GenPept AAB48941 AAH19946 AAH64799 BAE21958 BAE33854 BAF96749 CAJ18499 EDL12999
RNA Seq Atlas 11910