InnateDB Protein
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IDBP-57020.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MED14
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Protein Name
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mediator complex subunit 14
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Synonyms
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CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000323720
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InnateDB Gene
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IDBG-57018 (MED14)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269PubMed:15340088, ECO:0000269PubMed:15625066, ECO:0000269PubMed:16595664}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
88
[view]
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Protein-Protein |
83
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0003712
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transcription cofactor activity
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GO:0003713
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transcription coactivator activity
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GO:0004872
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receptor activity
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GO:0030374
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ligand-dependent nuclear receptor transcription coactivator activity
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GO:0042809
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vitamin D receptor binding
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GO:0046966
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thyroid hormone receptor binding
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0010467
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gene expression
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GO:0019827
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stem cell maintenance
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GO:0030518
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intracellular steroid hormone receptor signaling pathway
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GO:0030521
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androgen receptor signaling pathway
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR013947
Mediator complex, subunit Med14
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PFAM |
PF08638
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O60244
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PhosphoSite |
PhosphoSite-O60244
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9282
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UniGene |
Hs.609904
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RefSeq |
NP_004220
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HUGO |
HGNC:2370
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OMIM |
300182
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CCDS |
CCDS14254
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HPRD |
02172
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IMGT |
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EMBL |
AB006651
AB006652
AF104256
AF135802
AF304448
BC098377
BC132672
BC132674
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GenPept |
AAD12725
AAD24360
AAG22547
AAH98377
AAI32673
AAI32675
BAA28626
BAA28627
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