Homo sapiens Protein: IL17A
Summary
InnateDB Protein IDBP-90506.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17A
Protein Name interleukin 17A
Synonyms CTLA8; IL-17; IL-17A; IL17;
Species Homo sapiens
Ensembl Protein ENSP00000344192
InnateDB Gene IDBG-90504 (IL17A)
Protein Structure
UniProt Annotation
Function Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Restricted to activated memory T-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0006486 protein glycosylation
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0008219 cell death
GO:0032747 positive regulation of interleukin-23 production
GO:0045087 innate immune response (InnateDB)
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071347 cellular response to interleukin-1
GO:0072537 fibroblast activation
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR010345 Interleukin-17 family
IPR020440 Interleukin-17, chordata
IPR029034 Cystine-knot cytokine
PFAM PF06083
PRINTS PR01932
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16552
PhosphoSite PhosphoSite-Q16552
TrEMBL D9MX03
UniProt Splice Variant
Entrez Gene 3605
UniGene Hs.41724
RefSeq NP_002181
HUGO HGNC:5981
OMIM 603149
CCDS CCDS4937
HPRD 04396
IMGT
EMBL AL391221 AY460616 BC066251 BC066252 BC067503 BC067504 BC067505 CH471081 HM535222 U32659 Z58820
GenPept AAC50341 AAH66251 AAH66252 AAH67503 AAH67504 AAH67505 AAR23263 ADJ56412 CAA91233 CAI16678 EAX04362