InnateDB Protein
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IDBP-90506.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL17A
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Protein Name
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interleukin 17A
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Synonyms
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CTLA8; IL-17; IL-17A; IL17;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344192
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InnateDB Gene
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IDBG-90504 (IL17A)
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Protein Structure
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|
Function |
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Restricted to activated memory T-cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
|
Protein-Protein |
11
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR010345
Interleukin-17 family
IPR020440
Interleukin-17, chordata
IPR029034
Cystine-knot cytokine
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PFAM |
PF06083
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PRINTS |
PR01932
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16552
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PhosphoSite |
PhosphoSite-Q16552
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TrEMBL |
D9MX03
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UniProt Splice Variant |
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Entrez Gene |
3605
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UniGene |
Hs.41724
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RefSeq |
NP_002181
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HUGO |
HGNC:5981
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OMIM |
603149
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CCDS |
CCDS4937
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HPRD |
04396
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IMGT |
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EMBL |
AL391221
AY460616
BC066251
BC066252
BC067503
BC067504
BC067505
CH471081
HM535222
U32659
Z58820
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GenPept |
AAC50341
AAH66251
AAH66252
AAH67503
AAH67504
AAH67505
AAR23263
ADJ56412
CAA91233
CAI16678
EAX04362
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