InnateDB Protein
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IDBP-7255.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WHSC2
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Protein Name
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Wolf-Hirschhorn syndrome candidate 2
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Synonyms
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NELF-A; WHSC2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000372335
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InnateDB Gene
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IDBG-7253 (WHSC2)
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Protein Structure
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Function |
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex. {ECO:0000269PubMed:10199401, ECO:0000269PubMed:12563561, ECO:0000269PubMed:12612062}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11150502}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney. {ECO:0000269PubMed:10409432, ECO:0000269PubMed:11150502, ECO:0000269PubMed:12612062}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006368
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transcription elongation from RNA polymerase II promoter
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GO:0006414
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translational elongation
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GO:0007275
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multicellular organismal development
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GO:0010467
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gene expression
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GO:0016032
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viral process
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GO:0034244
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negative regulation of transcription elongation from RNA polymerase II promoter
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GO:0050434
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positive regulation of viral transcription
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H3P2
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PhosphoSite |
PhosphoSite-Q9H3P2
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TrEMBL |
C9JEM7
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UniProt Splice Variant |
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Entrez Gene |
7469
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UniGene |
Hs.708257
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RefSeq |
XP_006713980
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HUGO |
HGNC:12768
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OMIM |
606026
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CCDS |
CCDS3358
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HPRD |
12080
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IMGT |
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EMBL |
AB044549
AF101434
AF131751
AK094040
AK126056
AL132868
BC002764
CH471131
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GenPept |
AAC72982
AAD20034
AAH02764
BAB18651
BAG52802
BAG54283
CAM15219
EAW82546
EAW82547
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