InnateDB Protein
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IDBP-625971.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sp1
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Protein Name
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trans-acting transcription factor 1
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Synonyms
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1110003E12Rik; AA450830; AI845540; Sp1-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000130747
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InnateDB Gene
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IDBG-188607 (Sp1)
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Protein Structure
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Function |
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000250, ECO:0000269PubMed:24030830}.
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Subcellular Localization |
Nucleus. Cytoplasm {ECO:0000250}. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 256 interaction(s) predicted by orthology.
Experimentally validated |
Total |
60
[view]
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Protein-Protein |
41
[view]
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Protein-DNA |
19
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
256 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0000979
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RNA polymerase II core promoter sequence-specific DNA binding
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GO:0000987
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core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0001103
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RNA polymerase II repressing transcription factor binding
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GO:0003677
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DNA binding
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GO:0003690
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double-stranded DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0035326
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enhancer binding
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GO:0043425
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bHLH transcription factor binding
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GO:0043565
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sequence-specific DNA binding
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98372
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
O89090
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PhosphoSite |
PhosphoSite-O89090
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20683
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UniGene |
Mm.4618
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RefSeq |
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MGI ID |
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MGI Symbol |
Sp1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF022363
AF062566
S79832
X60136
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GenPept |
AAB35321
AAC08527
AAC16484
CAA42721
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