Mus musculus Protein: Sp1
Summary
InnateDB Protein IDBP-625971.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sp1
Protein Name trans-acting transcription factor 1
Synonyms 1110003E12Rik; AA450830; AI845540; Sp1-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000130747
InnateDB Gene IDBG-188607 (Sp1)
Protein Structure
UniProt Annotation
Function Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000250, ECO:0000269PubMed:24030830}.
Subcellular Localization Nucleus. Cytoplasm {ECO:0000250}. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 256 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 41 [view]
Protein-DNA 19 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 256 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0035326 enhancer binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001503 ossification
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030219 megakaryocyte differentiation
GO:0030324 lung development
GO:0043353 enucleate erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048706 embryonic skeletal system development
GO:0060136 embryonic process involved in female pregnancy
GO:0060216 definitive hemopoiesis
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:98372
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O89090
PhosphoSite PhosphoSite-O89090
TrEMBL
UniProt Splice Variant
Entrez Gene 20683
UniGene Mm.4618
RefSeq
MGI ID
MGI Symbol Sp1
OMIM
CCDS
HPRD
IMGT
EMBL AF022363 AF062566 S79832 X60136
GenPept AAB35321 AAC08527 AAC16484 CAA42721