InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mib1

Summary

InnateDB Protein

IDBP-621310.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mib1

Protein Name

mindbomb homolog 1 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131712

InnateDB Gene

IDBG-128545 (Mib1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. {ECO:0000250, ECO:0000269PubMed:12351649}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}. Cytoplasm. Cell membrane. Note=Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Localizes to the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in all tissues tested. Present in embryo, embryonic stem cells, bladder, skeletal muscle, bladder, uterus, testis, stomach, colon, ileum, trachea, lung, aorta, kidney, spleen, liver and vas deferens (at protein level). Highly expressed in testis. {ECO:0000269PubMed:12351649, ECO:0000269PubMed:15824097}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001841	neural tube formation
GO:0001947	heart looping
GO:0007219	Notch signaling pathway
GO:0007507	heart development
GO:0016567	protein ubiquitination
GO:0045665	negative regulation of neuron differentiation
GO:0045807	positive regulation of endocytosis

Cellular Component

GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0031410	cytoplasmic vesicle
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:2443157

InterPro

IPR000433 Zinc finger, ZZ-type
IPR001841 Zinc finger, RING-type
IPR002110 Ankyrin repeat
IPR010606 Mib-herc2
IPR020683 Ankyrin repeat-containing domain

PFAM