InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RX7

Summary

InnateDB Protein

IDBP-585487.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX7

Protein Name

purinergic receptor P2X, ligand-gated ion channel, 7

Synonyms

P2X7;

Species

Homo sapiens

Ensembl Protein

ENSP00000441230

InnateDB Gene

IDBG-61253 (P2RX7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005102	receptor binding
GO:0005216	ion channel activity
GO:0005524	ATP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007166	cell surface receptor signaling pathway
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0019233	sensory perception of pain
GO:0030501	positive regulation of bone mineralization
GO:0032060	bleb assembly
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045779	negative regulation of bone resorption
GO:0045919	positive regulation of cytolysis
GO:0046931	pore complex assembly
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0051495	positive regulation of cytoskeleton organization
GO:0051709	regulation of killing of cells of other organism
GO:0051899	membrane depolarization
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0032059	bleb