InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmga2

Summary

InnateDB Protein

IDBP-536123.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmga2

Protein Name

high mobility group AT-hook 2

Synonyms

9430083A20Rik; HMGI-C; Hmgic; pg; pygmy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123998

InnateDB Gene

IDBG-192646 (Hmga2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003680	AT DNA binding
GO:0005515	protein binding

Biological Process

GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0021846	cell proliferation in forebrain
GO:0021983	pituitary gland development
GO:0030325	adrenal gland development
GO:0035019	somatic stem cell maintenance
GO:0040018	positive regulation of multicellular organism growth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048712	negative regulation of astrocyte differentiation
GO:0060123	regulation of growth hormone secretion
GO:0060612	adipose tissue development
GO:0060613	fat pad development
GO:0090276	regulation of peptide hormone secretion
GO:2000648	positive regulation of stem cell proliferation

Cellular Component

GO:0000228	nuclear chromosome
GO:0000785	chromatin
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:101761

InterPro

IPR000116 High mobility group, HMG-I/HMG-Y
IPR017956 AT hook, DNA-binding motif
IPR020478 AT hook-like

PFAM

PF02178

PRINTS

PR00930
PR00929

PIRSF

SMART

SM00384

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q6NSP9

UniProt Splice Variant

Entrez Gene

15364

UniGene

Mm.473619

RefSeq

XP_006513314

MGI ID

MGI Symbol

Hmga2

OMIM

CCDS

HPRD

IMGT

EMBL

AC144783 BC069985

GenPept

AAH69985