InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IKBKB

Summary

InnateDB Protein

IDBP-473869.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IKBKB

Protein Name

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Synonyms

IKK-beta; IKK2; IKKB; IMD15; NFKBIKB;

Species

Homo sapiens

Ensembl Protein

ENSP00000430114

InnateDB Gene

IDBG-19987 (IKBKB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 300 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	300 [view]
Protein-Protein	297 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000626 Ubiquitin-like
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00240
PF14560
PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00213
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt