InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCAN

Summary

InnateDB Protein

IDBP-39618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCAN

Protein Name

neurocan

Synonyms

CSPG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000252575

InnateDB Gene

IDBG-39616 (NCAN)

Protein Structure

UniProt Annotation

Function

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0051823	regulation of synapse structural plasticity

Cellular Component

GO:0005576	extracellular region
GO:0005796	Golgi lumen
GO:0043202	lysosomal lumen

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000538 Link
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR001881 EGF-like calcium-binding domain
IPR002353 Type-2 ice-structuring protein
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold

PFAM

PF00084
PF00193
PF00008
PF00059
PF07645
PF07686

PRINTS

PR01265
PR00356

PIRSF

SMART

SM00032
SM00445
SM00181
SM00034
SM00179
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt