Version 5.4
Homo sapiens Protein: NF1
Summary
InnateDB Protein IDBP-374840.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NF1
Protein Name neurofibromin 1
Synonyms NFNS; VRNF; WSS;
Species Homo sapiens
Ensembl Protein ENSP00000389907
InnateDB Gene IDBG-39462 (NF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005488 binding
Biological Process
GO:0007165 signal transduction
GO:0032320 positive regulation of Ras GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR001251 CRAL-TRIO domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein
IPR016024 Armadillo-type fold
PFAM PF00650
PF13716
PF00616
PRINTS
PIRSF
SMART SM00516
SM00323
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q4W6X4
UniProt Splice Variant
Entrez Gene 4763
UniGene Hs.721732
RefSeq XP_006721988
HUGO HGNC:7765
OMIM 613113
CCDS
HPRD 01203
IMGT
EMBL AB195812 AB195813 AC004222 AC079915 AC134669 AC135724 AC138207 AC139072
GenPept BAD98998 BAD98999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca