InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ID2

Summary

InnateDB Protein

IDBP-27113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ID2

Protein Name

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

Synonyms

bHLHb26; GIG8; ID2A; ID2H;

Species

Homo sapiens

Ensembl Protein

ENSP00000234091

InnateDB Gene

IDBG-27111 (ID2)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269PubMed:20861012}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20861012}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:20861012}.

Disease Associations

Tissue Specificity

Highly expressed in early fetal tissues, including those of the central nervous system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044325	ion channel binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001656	metanephros development
GO:0001779	natural killer cell differentiation
GO:0002521	leukocyte differentiation
GO:0003149	membranous septum morphogenesis
GO:0003166	bundle of His development
GO:0007275	multicellular organismal development
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0009649	entrainment of circadian clock
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0014003	oligodendrocyte development
GO:0019216	regulation of lipid metabolic process
GO:0021772	olfactory bulb development
GO:0032922	circadian regulation of gene expression
GO:0033598	mammary gland epithelial cell proliferation
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0043353	enucleate erythrocyte differentiation
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045475	locomotor rhythm
GO:0045578	negative regulation of B cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045651	positive regulation of macrophage differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045777	positive regulation of blood pressure
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048468	cell development
GO:0048469	cell maturation
GO:0048541	Peyer's patch development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048663	neuron fate commitment
GO:0048711	positive regulation of astrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0060612	adipose tissue development
GO:0060749	mammary gland alveolus development
GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development
GO:0061031	endodermal digestive tract morphogenesis
GO:0071158	positive regulation of cell cycle arrest
GO:0071285	cellular response to lithium ion
GO:0071931	positive regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0090398	cellular senescence
GO:2000045	regulation of G1/S transition of mitotic cell cycle
GO:2000178	negative regulation of neural precursor cell proliferation