InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHD3

Summary

InnateDB Protein

IDBP-27059.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD3

Protein Name

chromodomain helicase DNA binding protein 3

Synonyms

Mi-2a; Mi2-ALPHA; ZFH;

Species

Homo sapiens

Ensembl Protein

ENSP00000350907

InnateDB Gene

IDBG-27053 (CHD3)

Protein Structure

UniProt Annotation

Function

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. {ECO:0000269PubMed:17626165, ECO:0000269PubMed:9804427}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17626165}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:17626165}. Note=Associates with centrosomes in interphase and mitosis.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9688266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 190 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	190 [view]
Protein-Protein	189 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007051	spindle organization
GO:0016568	chromatin modification
GO:0032508	DNA duplex unwinding
GO:0051297	centrosome organization

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016581	NuRD complex
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR000953 Chromo domain/shadow
IPR001650 Helicase, C-terminal
IPR001965 Zinc finger, PHD-type
IPR006935 Helicase/UvrB domain
IPR009071 High mobility group box domain
IPR009462 Domain of unknown function DUF1086
IPR009463 Domain of unknown function DUF1087
IPR011011 Zinc finger, FYVE/PHD-type
IPR012957 CHD, C-terminal 2
IPR012958 CHD, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016197 Chromo domain-like
IPR019787 Zinc finger, PHD-finger
IPR021006 Histone deacetylase complex, subunit 2/3
IPR023780 Chromo domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM