InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Coasy

Summary

InnateDB Protein

IDBP-266946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Coasy

Protein Name

Coenzyme A synthase

Synonyms

1300003G02Rik; Dpck; Ppat; Ukr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102929

InnateDB Gene

IDBG-211816 (Coasy)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but this protein is also present in cell lysate. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in kidney and lowest levels in colon, lung, intestine, and spleen. {ECO:0000269PubMed:11980892}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004140	dephospho-CoA kinase activity
GO:0004595	pantetheine-phosphate adenylyltransferase activity
GO:0005515	protein binding
GO:0005524	ATP binding