Homo sapiens Protein: ARHGAP17 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-21393.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | ARHGAP17 | ||||||||||||||||||
Protein Name | Rho GTPase activating protein 17 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000303130 | ||||||||||||||||||
InnateDB Gene | IDBG-21389 (ARHGAP17) | ||||||||||||||||||
Protein Structure |
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UniProt Annotation | |||||||||||||||||||
Function | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269PubMed:11431473, ECO:0000269PubMed:16678097}. | ||||||||||||||||||
Subcellular Localization | Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Ubiquitously expressed. Expressed at higher level in heart and placenta. {ECO:0000269PubMed:11431473}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000198
Rho GTPase-activating protein domain IPR004148 BAR domain IPR008936 Rho GTPase activation protein |
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PFAM |
PF00620
PF03114 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00324
SM00721 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q68EM7 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q68EM7 | ||||||||||||||||||
TrEMBL | I3L4P6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 55114 | ||||||||||||||||||
UniGene | Hs.596568 | ||||||||||||||||||
RefSeq | NP_060524 | ||||||||||||||||||
HUGO | HGNC:18239 | ||||||||||||||||||
OMIM | 608293 | ||||||||||||||||||
CCDS | CCDS32408 | ||||||||||||||||||
HPRD | 12207 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC008731 AC010545 AF163257 AF173885 AJ306731 AJ306732 AK001170 AK023281 AK027567 AK125358 AK291691 AL833975 BC001241 BC080195 | ||||||||||||||||||
GenPept | AAH01241 AAH80195 AAQ13586 AAQ13632 BAB14506 BAB55203 BAC86144 BAF84380 CAC37948 CAC37949 CAD38819 | ||||||||||||||||||