InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP17

Summary

InnateDB Protein

IDBP-21391.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP17

Protein Name

Rho GTPase activating protein 17

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000289968

InnateDB Gene

IDBG-21389 (ARHGAP17)

Protein Structure

UniProt Annotation

Function

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269PubMed:11431473, ECO:0000269PubMed:16678097}.

Subcellular Localization

Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed at higher level in heart and placenta. {ECO:0000269PubMed:11431473}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction