InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmga2

Summary

InnateDB Protein

IDBP-192648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmga2

Protein Name

high mobility group AT-hook 2

Synonyms

9430083A20Rik; HMGI-C; Hmgic; pg; pygmy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072556

InnateDB Gene

IDBG-192646 (Hmga2)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. {ECO:0000269PubMed:14668482}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14668482}.

Disease Associations

Tissue Specificity

Expressed in mitotic spermatogonia, meiotic spermatocytes, and postmeiotic round spermatids (at protein level). {ECO:0000269PubMed:14668482}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0000988	protein binding transcription factor activity
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003680	AT DNA binding
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004677	DNA-dependent protein kinase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0019899	enzyme binding
GO:0031492	nucleosomal DNA binding
GO:0035497	cAMP response element binding
GO:0035500	MH2 domain binding
GO:0035501	MH1 domain binding
GO:0046332	SMAD binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000737	DNA catabolic process, endonucleolytic
GO:0001837	epithelial to mesenchymal transition
GO:0002062	chondrocyte differentiation
GO:0003131	mesodermal-endodermal cell signaling
GO:0006284	base-excision repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0007126	meiotic nuclear division
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0009615	response to virus
GO:0010564	regulation of cell cycle process
GO:0010628	positive regulation of gene expression
GO:0021846	cell proliferation in forebrain
GO:0021983	pituitary gland development
GO:0030261	chromosome condensation
GO:0030325	adrenal gland development
GO:0031052	chromosome breakage
GO:0031507	heterochromatin assembly
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0035019	somatic stem cell maintenance
GO:0035978	histone H2A-S139 phosphorylation
GO:0035986	senescence-associated heterochromatin focus assembly
GO:0035987	endodermal cell differentiation
GO:0035988	chondrocyte proliferation
GO:0040018	positive regulation of multicellular organism growth
GO:0042769	DNA damage response, detection of DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043922	negative regulation by host of viral transcription
GO:0045444	fat cell differentiation
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046426	negative regulation of JAK-STAT cascade
GO:0048333	mesodermal cell differentiation
GO:0048712	negative regulation of astrocyte differentiation
GO:0048762	mesenchymal cell differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060123	regulation of growth hormone secretion
GO:0060612	adipose tissue development
GO:0060613	fat pad development
GO:0071158	positive regulation of cell cycle arrest
GO:0090276	regulation of peptide hormone secretion
GO:0090402	oncogene-induced cell senescence
GO:2000036	regulation of stem cell maintenance
GO:2000648	positive regulation of stem cell proliferation
GO:2000679	positive regulation of transcription regulatory region DNA binding
GO:2000685	positive regulation of cellular response to X-ray
GO:2000774	positive regulation of cellular senescence
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining
GO:2001038	regulation of cellular response to drug

Cellular Component

GO:0000228	nuclear chromosome
GO:0005634	nucleus
GO:0032993	protein-DNA complex
GO:0035985	senescence-associated heterochromatin focus
GO:0071141	SMAD protein complex