InnateDB Protein
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IDBP-181767.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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D10Wsu52e
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Protein Name
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DNA segment, Chr 10, Wayne State University 52, expressed
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Synonyms
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AI255213; AI463255; D10Wsu52e; FAAP; HSPC117;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000001834
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InnateDB Gene
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IDBG-181765 (D10Wsu52e)
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Protein Structure
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Function |
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity). Essential during post-implantation development of embryos. {ECO:0000250, ECO:0000269PubMed:20510672}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000255HAMAP-Rule:MF_03144, ECO:0000269PubMed:18508721}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Highly expressed in the epididymis with predominant enrichment in the initial segment. During sexual maturation, it is expressed in the caput epididymides. {ECO:0000269PubMed:21046479}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
20 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106379
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InterPro |
IPR001233
tRNA-splicing ligase, RtcB
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PFAM |
PF01139
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99LF4
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PhosphoSite |
PhosphoSite-Q99LF4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
28088
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UniGene |
Mm.9257
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RefSeq |
NP_663397
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MGI ID |
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MGI Symbol |
Rtcb
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OMIM |
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CCDS |
CCDS24094
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HPRD |
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IMGT |
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EMBL |
AK145891
AK145916
AK149885
AK150376
AK150470
AK151042
AK151182
AK151932
AK152144
AK153434
AK168038
AK172175
AY424364
BC003288
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GenPept |
AAH03288
AAR02005
BAE26729
BAE26747
BAE29145
BAE29508
BAE29587
BAE30059
BAE30183
BAE30808
BAE30981
BAE31991
BAE40021
BAE42866
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