Version 5.4
Mus musculus Protein: Nod2
Summary
InnateDB Protein IDBP-179052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nod2
Protein Name nucleotide-binding oligomerization domain containing 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000050538
InnateDB Gene IDBG-179050 (Nod2)
Protein Structure
UniProt Annotation
Function Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response. {ECO:0000269PubMed:22607974}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0032500 muramyl dipeptide binding
GO:0042834 peptidoglycan binding
GO:0050700 CARD domain binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0002227 innate immune response in mucosa
GO:0002253 activation of immune response
GO:0002367 cytokine production involved in immune response
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002710 negative regulation of T cell mediated immunity
GO:0002732 positive regulation of dendritic cell cytokine production
GO:0002830 positive regulation of type 2 immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0006963 positive regulation of antibacterial peptide biosynthetic process
GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007165 signal transduction
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell proliferation
GO:0009595 detection of biotic stimulus
GO:0016045 detection of bacterium
GO:0030277 maintenance of gastrointestinal epithelium
GO:0031398 positive regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032494 response to peptidoglycan
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0032498 detection of muramyl dipeptide
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032701 negative regulation of interleukin-18 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0035419 activation of MAPK activity involved in innate immune response
GO:0035556 intracellular signal transduction
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 positive regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051259 protein oligomerization
GO:0051353 positive regulation of oxidoreductase activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0071407 cellular response to organic cyclic compound
GO:0071608 macrophage inflammatory protein-1 alpha production
GO:0090022 regulation of neutrophil chemotaxis
GO:2000110 negative regulation of macrophage apoptotic process
GO:2000363 positive regulation of prostaglandin-E synthase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0008180 COP9 signalosome
GO:0009986 cell surface
GO:0031982 vesicle
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2429397
InterPro IPR001315 CARD domain
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00619
PRINTS
PIRSF
SMART SM00114
SM00368
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K3Z0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 257632
UniGene Mm.222633
RefSeq
MGI ID
MGI Symbol Nod2
OMIM
CCDS
HPRD
IMGT
EMBL AF520774 BC044774
GenPept AAH44774 AAM76073

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca